I was asked to compose my thought regarding Eclipse Phase, and as I take requests. Let me do so, without much wait.
Note that my thoughts are based on reading the book a few times, and a half-assed one shot run by a GM who meant well, but didn't know the system.
And Eclipse Phase is not a system that is kind to people who don't know the game. Key items: It is percentile based, your characters are built off 1000 points, and you have nearly endless variety in the bodies you can sleeve your mind into. In case that seems like a totally alien and weird concept, I suggest the wikipedia article about it.
There is no way to model that sort of wide flexibility with actual mechanical differentiation without an overly complex system. The question is, of course, where does the complexity come in? It appears the complexity comes in when you create your character and change bodies. Otherwise the system is fairly easy - blackjack d100 (i.e., roll as close as you can to your adjusted skill without going over, doubles (00, 11, 22, 33...) are critical, beating an opposed roll by 30+ points is an exception success). That's basically it, there's remembering what your equipment does, but that can be easily cheat sheet away.
Except combat. Combat is crunchy as all hell, and what's worse, is the damage system is non-intuitive. You have Durability which is your total hit points, but your Wound Threshold is when you take penalties. As numbers on a sheet this is incredibly annoying, and would have been better served with boxes, ala White Wolf. How does it work?
One character has Durability 40, Wound Threshold 10; another has Durability 40; Wound Threshold 8. If they both take 8 points of damage, the second character is at a -10 to all actions, the first character is fine; if they both take 20 points of damage, both characters are at -20 (10/20; 8/16); and at 40 both are down and out. The problem with graphically representing this is that the first character will need 4 lines (No penalty/-10/-20/-30); while the second character would need five lines for the additional -40 penalty. If I was playing I'd just make a damage tracking side sheet.
But that just adds to the complexity.
Does Eclipse Phase do what it intends to do? Yes. It provides the verisimilitude of what I'd consider a Transhuman Horror universe to look like. Unfortunately, there's no clean smooth way to do this except by using a lot of numbers, and a lot of crunching. That means that for many of the people I game with, despite the numbers being primarily frontloaded, it is still going to be an uphill battle.
But do I want to play or run a game? Yes, to the first, and probably to the second. The latter will just require finding players who found older editions of Shadowrun not that crunchy.
Good: Flexibility, Theme, Mechanics
Bad: Non-intuitive calculations in combat.
Recommendation: Assuming a group that is okay with the buy-in to character creation and the math of combat, yes. As the system is available for free on PDF under the CCL, there's no reason to at least read it over. I did and bought the hard cover because of it.